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Significantly decreased tumor area is observed by AZD3759 treatment at the doses of 7
It inhibits the proliferation of lung cancer cells[1]
at more physiologically relevant concentrations (IC50 = 66 nM) when Flavopiridol is tested in the National Cancer Institute Development Therapeutics Program panel of 60 human tumor cell lines
1051/medsci/20132910007
1 nM for APP23 and APP51/16 in primary neurons
PNU-159682 60424 Significantly decreased tumor area isPNU 159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. PNU 159682 showed > 3,000 fold cytotoxic than its parent compound(MMDX and doxorubicin). PNU 159682 interacts with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) and shows a strong but reversible binding to G: C base pairs. Product information CAS Number: 202350 68 3 Molecular Weight: 641. 62 Formula: C32H35NO13 Synonym: PNU159682 PNU 159682 Chemical